The Sprockett Lab

Our lab studies the ecology and evolution of the human microbiome, with a central focus on how host-associated microbial communities assemble in early life, transmit between individuals, and adapt to new hosts and environments. Critically, we also want to improve our understanding of these processes in order to design effective microbiome-based therapies and management approaches to improve human health and wellbeing.

To tackle these and related questions, we use high-throughput genomic and metagenomic approaches across a diverse range of experimental and natural systems, including conventionally-raised, germ-free, and rewilded mouse models; nonhuman primate models; and clinical and cohort-based studies in humans. By fusing experimental and computational approaches with ecological and evolutionary theory, we aim to generate new insights into how the microbiome develops, adapts, and influences health across the host lifespan.

In addition, we believe that training the next generation of scientists is as fundamental to our mission as the research itself. We strive to create a lab culture where rigorous, reproducible science goes hand in hand with collaboration, mentorship, and intellectual generosity. We believe the best science is done in environments are those where critical thinking is essential, curiosity is encouraged, team members at all career stages contribute meaningfully to our shared goals.